|Other Accession||NM_019080, NP_061953|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Chicken, Horse, Bovine, Dog|
|Alias Symbol||FLJ25842, KIAA1165, N4wbp5a, N4WBP5A|
|Other Names||NEDD4 family-interacting protein 2, NEDD4 WW domain-binding protein 5A, Putative MAPK-activating protein PM04/PM05/PM06/PM07, Putative NF-kappa-B-activating protein 413, NDFIP2, KIAA1165, N4WBP5A|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-NDFIP2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||NDFIP2 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. May modulate EGFR signaling.|
|Cellular Location||Endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane. Endosome, multivesicular body membrane|
|Tissue Location||Expressed in brain, lung, heart, skeletal muscle, kidney, liver and placenta.|
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Provided below are standard protocols that you may find useful for product applications.
Cristillo A.D.,et al.J. Biol. Chem. 278:34587-34597(2003).
Matsuda A.,et al.Oncogene 22:3307-3318(2003).
Dunham A.,et al.Nature 428:522-528(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hirosawa M.,et al.DNA Res. 6:329-336(1999).
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