|Application ||WB, IP|
|Other Accession||NM_020728, NP_065779|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||CHR2SYT, ESYT2, KIAA1228, E-Syt2, FAM62B|
|Other Names||Extended synaptotagmin-2, E-Syt2, Chr2Syt, ESYT2, FAM62B, KIAA1228|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-FAM62B antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||FAM62B antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex.|
|Cellular Location||Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein Note=Detected at sites of contact between the endoplasmic reticulum membrane and the cell membrane. Recruited to the cell membrane via the third C2 domain|
|Tissue Location||Widely expressed with high level in cerebellum.|
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Provided below are standard protocols that you may find useful for product applications.
Min S.-W.,et al.Proc. Natl. Acad. Sci. U.S.A. 104:3823-3828(2007).
Shan Y.X.,et al.Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.W.,et al.Science 300:767-772(2003).
Nagase T.,et al.DNA Res. 6:337-345(1999).
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