|Other Accession||NM_024312, NP_077288|
|Reactivity||Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Chicken, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||DKFZp762B226, GNPTA, ICD, KIAA1208, MGC4170|
|Other Names||N-acetylglucosamine-1-phosphotransferase subunits alpha/beta, 220.127.116.11, GlcNAc-1-phosphotransferase subunits alpha/beta, Stealth protein GNPTAB, UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta, N-acetylglucosamine-1-phosphotransferase subunit alpha, N-acetylglucosamine-1-phosphotransferase subunit beta, GNPTAB, GNPTA, KIAA1208|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-GNPTAB antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||GNPTAB antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment.|
|Cellular Location||N-acetylglucosamine-1-phosphotransferase subunit alpha: Golgi apparatus membrane; Single- pass type I membrane protein|
|Tissue Location||Expressed in the heart, whole brain, placenta, lung, liver, skeletal muscle, kidney and pancreas|
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Provided below are standard protocols that you may find useful for product applications.
Tiede S.,et al.Nat. Med. 11:1109-1112(2005).
Kudo M.,et al.J. Biol. Chem. 280:36141-36149(2005).
Kudo M.,et al.J. Biol. Chem. 280:42476-42476(2005).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nagase T.,et al.DNA Res. 6:337-345(1999).
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