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H13 antibody - middle region

Rabbit Polyclonal Antibody

  • WB - H13 antibody - middle region AI13107

    WB Suggested Anti-H13 Antibody Titration: 1.0 μg/ml
    Positive Control: Mouse Spleen
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9D8V0
Other Accession NM_010376, NP_034506
Reactivity Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 42kDa
Additional Information
Gene ID 14950
Alias Symbol 1200006O09Rik, 4930443L17Rik, 5031424B04Rik, AV020344, H-13, Hm13, PSL3, Spp
Other Names Minor histocompatibility antigen H13, 3.4.23.-, Presenilin-like protein 3, Signal peptide peptidase, Hm13, H13, Psl3
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-H13 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsH13 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Hm13
Synonyms H13, Psl3
Function Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. Involved in the intramembrane cleavage of the integral membrane protein PSEN1. Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner (By similarity). May play a role in graft rejection.
Cellular Location Endoplasmic reticulum membrane; Multi- pass membrane protein
Tissue Location Widely expressed with highest levels in liver and kidney. In the brain, expressed predominantly in hippocampus, amygdala, piriform cortex, choroid plexus and arcuate nucleus of the hypothalamic area. Isoform 1 is more strongly expressed than isoform 4 in most tissues except brain and skeletal muscle where isoform 4 is the dominant isoform and in testis where isoform 1 and isoform 4 are expressed at similar levels. In the brain, isoform 4 is not detected in the choroid plexus
Citations (0)

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Urny J.,et al.Gene Expr. Patterns 3:685-691(2003).
Urny J.,et al.Biochim. Biophys. Acta 1759:159-165(2006).
Irmler M.,et al.Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
Brown A.C.,et al.Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
Carninci P.,et al.Science 309:1559-1563(2005).

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$ 293.00
Cat# AI13107
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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