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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   UNC93B1 antibody - N-terminal region   

UNC93B1 antibody - N-terminal region

Rabbit Polyclonal Antibody

  • WB - UNC93B1 antibody - N-terminal region AI13109

    WB Suggested Anti-UNC93B1 Antibody Titration: 5.0μg/ml
    Positive Control: Jurkat cell lysate
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9H1C4
Other Accession NM_030930, NP_112192
Reactivity Human, Mouse, Rat, Pig, Horse, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Rat, Horse, Guinea Pig
Host Rabbit
Clonality Polyclonal
Calculated MW 67kDa
Additional Information
Gene ID 81622
Alias Symbol MGC126617, UNC93, UNC93B, IIAE1, Unc-93B1
Other Names Protein unc-93 homolog B1, Unc-93B1, hUNC93B1, UNC93B1, UNC93, UNC93B
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 100 ul of distilled water. Final anti-UNC93B1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsUNC93B1 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name UNC93B1
Synonyms UNC93, UNC93B
Function Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B- cells removal.
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Endosome. Lysosome. Cytoplasmic vesicle, phagosome. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon cell-stimulation with CpG dinucleotides (By similarity). Colocalizes with LAMP5 in large endosomal intracellular vesicles. {ECO:0000250, ECO:0000269|PubMed:18082565, ECO:0000269|PubMed:21642595}
Tissue Location Expressed in plasmocytoid dendritic cells (at protein level). Highly expressed in antigen-presenting cells Expressed in heart, and at lower level in kidney. Expressed at low level in other tissues.
Research Areas
Citations (0)

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Kashuba V.I.,et al.Gene 283:209-217(2002).
Taylor T.D.,et al.Nature 440:497-500(2006).
Kollewe A.,et al.Thesis (2001), University of Hannover, Germany.
Olsen J.V.,et al.Cell 127:635-648(2006).
Casrouge A.,et al.Science 314:308-312(2006).

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$ 232.00
Cat# AI13109
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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