|Other Accession||NM_031418, NP_113606|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Chicken, Bovine, Dog|
|Alias Symbol||C11orf25, GENX-3947, TMEM16C|
|Other Names||Anoctamin-3, Transmembrane protein 16C, ANO3, C11orf25, TMEM16C|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-TMEM16C antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||TMEM16C antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide. Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Note=Shows an intracellular localization.|
|Tissue Location||Highly expressed in the forebrain striatum.|
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Provided below are standard protocols that you may find useful for product applications.
Rosier M.F.,et al.Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Taylor T.D.,et al.Nature 440:497-500(2006).
Duran C.,et al.Acta Pharmacol. Sin. 32:685-692(2011).
Kunzelmann K.,et al.Pflugers Arch. 462:195-208(2011).
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