|Other Accession||NM_026384, NP_080660|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Goat, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||0610010B06Rik, DGAT-2|
|Other Names||Diacylglycerol O-acyltransferase 2, 22.214.171.124, Acyl-CoA retinol O-fatty-acyltransferase, ARAT, Retinol O-fatty-acyltransferase, 126.96.36.199, Diglyceride acyltransferase 2, Dgat2|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Dgat2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Dgat2 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides. Functions also as an acyl-CoA retinol acyltransferase (ARAT) (By similarity).|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein. Lipid droplet|
|Tissue Location||Predominantly expressed in liver. Also expressed in testis.|
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Provided below are standard protocols that you may find useful for product applications.
Cases S.,et al.J. Biol. Chem. 276:38870-38876(2001).
Carninci P.,et al.Science 309:1559-1563(2005).
Meegalla R.L.,et al.Biochem. Biophys. Res. Commun. 298:317-323(2002).
Wakimoto K.,et al.Biochem. Biophys. Res. Commun. 310:296-302(2003).
Stone S.J.,et al.J. Biol. Chem. 279:11767-11776(2004).
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