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>   home   >   Products   >   Primary Antibodies   >   Cardiovascular   >   WDFY3 antibody - middle region   

WDFY3 antibody - middle region

Rabbit Polyclonal Antibody

  • WB - WDFY3 antibody - middle region AI13239

    WB Suggested Anti-WDFY3 Antibody Titration: 0.2-1 μg/ml
    ELISA Titer: 1:12500
    Positive Control: Human Muscle
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8IZQ1
Other Accession NM_178583, NP_848698
Reactivity Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 90kDa
Additional Information
Gene ID 23001
Alias Symbol ALFY, KIAA0993, MGC16461, ZFYVE25
Other Names WD repeat and FYVE domain-containing protein 3, Autophagy-linked FYVE protein, Alfy, WDFY3, KIAA0993
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-WDFY3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsWDFY3 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name WDFY3
Synonyms KIAA0993
Function Required for selective autophagy (aggrephagy) but not for autophagic degradation of bulk cytospol in response to starvation. Involved in the formation and degradation of cytoplasmic polyubiquitin-containing bodies (p62 bodies, ALIS/aggresome-like induced structures). May play a role as adaptor or scaffolding protein by promoting the association of the E3-like ligase ATG12-ATG5-ATG16L and LC3 to ubiquitinated target substrate. The association with GABARAP is required for its recruitment to LC3B-positive p62 bodies suggesting a role in targeting certain p62 structures for clearance. Involved in midbody ring degradation.
Cellular Location Nucleus membrane. Cytoplasm. Nucleus, PML body. Membrane; Peripheral membrane protein; Cytoplasmic side Note=Colocalizes with autophagic structures in starved cells Shuttles between nucleus and cytoplasm; translocation from the nucleus to cytoplasmic polyubiquitin-containing bodies upon cellular stress is dependent on SQSTM1
Tissue Location Ubiquitous. Expressed in osteoclast and their mononuclear precursors (at protein level)
Research Areas
Citations (0)

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Simonsen A.,et al.J. Cell Sci. 117:4239-4251(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
Nagase T.,et al.DNA Res. 6:63-70(1999).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 293.00
Cat# AI13239
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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