|Other Accession||NM_001018091, NP_001018101|
|Reactivity||Human, Mouse, Rat, Rabbit, Horse, Yeast, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||FLJ30973, GRINL1A, Gcom2, Gup1, Gup2, MGC126694, MGC138353, gcom, MYZAP-POLR2M|
|Other Names||Myocardial zonula adherens protein, GRINL1A upstream protein, Gup, MYZAP, MYOZAP|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Gcom1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Gcom1 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in cellular signaling via Rho-related GTP- binding proteins and subsequent activation of transcription factor SRF (By similarity). Targets TJP1 to cell junctions. In cortical neurons, may play a role in glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1 (By similarity).|
|Cellular Location||Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, myofibril, sarcomere, I band. Cytoplasm, myofibril, sarcomere, Z line. Cell junction. Note=Detected predominantly at the intercalated disk in cardiomyocytes, and at low levels on sarcomeric Z disks. Colocalizes with F-actin. Colocalizes with cortical actin (By similarity).|
|Tissue Location||Detected in heart, liver, skeletal muscle, placenta, small intestine, lung, prostate and testis|
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Provided below are standard protocols that you may find useful for product applications.
Roginski R.S.,et al.Genomics 84:265-276(2004).
Seeger T.S.,et al.Circ. Res. 106:880-890(2010).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:671-675(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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