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Smpdl3a antibody - N-terminal region
Rabbit Polyclonal Antibody
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Application 
| WB |
|---|---|
| Primary Accession | P70158 |
| Other Accession | NM_020561, NP_065586 |
| Reactivity | Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog |
| Predicted | Mouse, Rabbit, Pig, Horse, Guinea Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 49kDa |
| Gene ID | 57319 |
|---|---|
| Alias Symbol | 0610010C24Rik, AI529588, ASM3A, ASML3, ASML3A |
| Other Names | Acid sphingomyelinase-like phosphodiesterase 3a, ASM-like phosphodiesterase 3a, 3.1.4.-, Smpdl3a, Asml3a |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Smpdl3a antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Smpdl3a antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Smpdl3a {ECO:0000303|PubMed:25288789, ECO:0000312|MGI:MGI:1931437} |
|---|---|
| Function | Cyclic-nucleotide phosphodiesterase that acts as a negative regulator of innate immunity by mediating degradation of 2',3'-cGAMP, thereby inhibiting the cGAS-STING signaling (PubMed:37890481). Specifically linearizes 2',3'-cGAMP into 2'5'-bond pGpA and further hydrolyzes pGpA to produce GpA (By similarity). Also has in vitro nucleotide phosphodiesterase activity with nucleoside triphosphates, such as ATP (PubMed:26792860). Has in vitro activity with p- nitrophenyl-TMP (By similarity). Has lower activity with nucleoside diphosphates, and no activity with nucleoside monophosphates (By similarity). Has in vitro activity with CDP-choline, giving rise to CMP and phosphocholine (By similarity). Has in vitro activity with CDP- ethanolamine (By similarity). Does not have sphingomyelin phosphodiesterase activity (By similarity). |
| Cellular Location | Secreted |
| Tissue Location | Detected in blood serum (at protein level). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Hofmann K.,et al.Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases.
Carninci P.,et al.Science 309:1559-1563(2005).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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