|Other Accession||NM_022015, NP_071298|
|Reactivity||Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Chicken, Horse, Bovine, Dog|
|Alias Symbol||AW260255, Tbn|
|Other Names||Transcription initiation factor TFIID subunit 8, Protein taube nuss, TBP-associated factor 8, Taf8, Tbn|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Taf8 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Taf8 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex (By similarity). May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo.|
|Cellular Location||Nucleus. Cytoplasm. Note=Localized in the cytoplasm and transported from the cytoplasm to the nucleus in some cells, possibly depending on the functional or developmental state of the cell|
|Tissue Location||Low level of expression throughout the brain with slightly higher expression in the hippocampus|
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Provided below are standard protocols that you may find useful for product applications.
Voss A.K.,et al.Development 127:5449-5461(2000).
Carninci P.,et al.Science 309:1559-1563(2005).
Guermah M.,et al.Mol. Cell 12:991-1001(2003).
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