|Other Accession||NM_144996, NP_659433|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Yeast, Bovine, Dog|
|Predicted||Human, Horse, Dog|
|Calculated MW||37 KDa|
|Alias Symbol||ARL2L1, DKFZp686E2075, DKFZp686L2472, DKFZp686M2074, DKFZp761H079, MGC120611, MGC120612, JBTS8|
|Other Names||ADP-ribosylation factor-like protein 13B, ADP-ribosylation factor-like protein 2-like 1, ARL2-like protein 1, ARL13B, ARL2L1|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-ARL13B antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||ARL13B antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic interneurons in the developing cerebral cortex. May regulate endocytic recycling traffic; however, additional evidences are required to confirm these data.|
|Cellular Location||Cell projection, cilium membrane; Lipid- anchor Note=Associates to the cilium membrane via palmitoylation Localizes to proximal ciliary membranes, to an inversin-like subciliary membrane compartment, excluding the transition zone|
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Provided below are standard protocols that you may find useful for product applications.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Fan Y.,et al.Nat. Genet. 36:989-993(2004).
Hori Y.,et al.Biochem. Biophys. Res. Commun. 373:119-124(2008).
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