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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   PIWIL4 antibody - N-terminal region   

PIWIL4 antibody - N-terminal region

Rabbit Polyclonal Antibody

  • WB - PIWIL4 antibody - N-terminal region AI13488

    WB Suggested Anti-PIWIL4 Antibody Titration: 0.2-1 μg/ml
    Positive Control: HT1080 cell lysate
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q7Z3Z4
Other Accession NM_152431, NP_689644
Reactivity Human
Predicted Human
Host Rabbit
Clonality Polyclonal
Calculated MW 96 KDa
Additional Information
Gene ID 143689
Alias Symbol DKFZp686P01248, FLJ36156, HIWI2, MIWI2
Other Names Piwi-like protein 4, PIWIL4, HIWI2, PIWI
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-PIWIL4 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsPIWIL4 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms HIWI2, PIWI
Function Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer- independent mechanism and are primarily derived from transposons and other repeated sequence elements. Associates with secondary piRNAs antisense and PIWIL2/MILI is required for such association. The piRNA process acts upstream of known mediators of DNA methylation. Participates in a piRNA amplification loop. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity). May be involved in the chromatin-modifying pathway by inducing 'Lys-9' methylation of histone H3 at some loci.
Cellular Location Nucleus. Cytoplasm. Note=Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. PIWIL2/MILI is required for nuclear localization (By similarity).
Tissue Location Expressed in testis. According to PubMed:17544373, it is ubiquitously expressed
Research Areas
Citations (0)

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Sasaki T.,et al.Genomics 82:323-330(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Sugimoto K.,et al.Biochem. Biophys. Res. Commun. 359:497-502(2007).

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$ 293.00
Cat# AI13488
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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