SASP antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q53RT3 |
Other Accession | NM_152792, NP_690005 |
Reactivity | Human, Rat, Horse, Guinea Pig |
Predicted | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 37kDa |
Gene ID | 151516 |
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Alias Symbol | MUNO, SASPase, Taps, SASP |
Other Names | Retroviral-like aspartic protease 1, 3.4.23.-, Skin-specific retroviral-like aspartic protease, SASPase, Skin aspartic protease, TPA-inducible aspartic proteinase-like protein, TAPS, ASPRV1 {ECO:0000250|UniProtKB:Q09PK2} |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-SASP antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | SASP antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ASPRV1 (HGNC:26321) |
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Function | Protease responsible for filaggrin processing, essential for the maintenance of a proper epidermis organization. |
Cellular Location | Membrane; Single-pass membrane protein |
Tissue Location | Expressed primarily in the granular layer of the epidermis and inner root sheath of hair follicles. In psoriatic skin, expressed throughout the stratum corneum. In ulcerated skin, expressed in the stratum granulosum of intact epidermis but almost absent from ulcerated regions. Expressed in differentiated areas of squamous cell carcinomas but not in undifferentiated tumors |
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Provided below are standard protocols that you may find useful for product applications.
References
Bernard D.,et al.J. Invest. Dermatol. 125:278-287(2005).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
Rhiemeier V.,et al.Am. J. Pathol. 168:1354-1364(2006).
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