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Nbr1 antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P97432 |
| Other Accession | NM_008676, NP_032702 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Dog |
| Predicted | Human, Mouse, Rat, Rabbit, Horse, Bovine, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 109kDa |
| Gene ID | 17966 |
|---|---|
| Alias Symbol | mKIAA0049 |
| Other Names | Next to BRCA1 gene 1 protein, Membrane component chromosome 17 surface marker 2 homolog, Neighbor of BRCA1 gene 1 protein, Nbr1, M17s2 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Nbr1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Nbr1 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Nbr1 |
|---|---|
| Synonyms | M17s2 |
| Function | Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis (PubMed:31916398, PubMed:34374750). Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates. Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation (By similarity). In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation (PubMed:31916398). In turn, activates the KEAP1- NRF2/NFE2L2 antioxidant pathway (PubMed:31916398). Plays also non- autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion (PubMed:34374750). |
| Cellular Location | Cytoplasm. Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:Q14596} Lysosome {ECO:0000250|UniProtKB:Q14596}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000250|UniProtKB:Q501R9}. Note=In cardiac muscles localizes to the sarcomeric M line (By similarity). Is targeted to lysosomes for degradation (By similarity) {ECO:0000250|UniProtKB:Q14596, ECO:0000250|UniProtKB:Q501R9, ECO:0000269|PubMed:31916398} |
| Tissue Location | Expressed in brain. |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Chambers J.A.,et al.Genomics 38:305-313(1996).
Dimitrov S.,et al.Gene 262:89-98(2001).
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$ 389.00
Cat# AI13592
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