|Other Accession||NM_001081108, NP_001074577|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Bovine, Guinea Pig, Dog|
|Alias Symbol||AV006840, 0910001L09Rik|
|Other Names||Ragulator complex protein LAMTOR4, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4, Ragulator complex protein LAMTOR4, N-terminally processed, Lamtor4|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-0910001L09Rik antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||0910001L09Rik antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
Carninci P.,et al.Science 309:1559-1563(2005).
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