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MPEG1 antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q2M385 |
| Other Accession | NM_001039396, NP_001034485 |
| Reactivity | Human |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 78kDa |
| Gene ID | 219972 |
|---|---|
| Alias Symbol | MGC132657, MGC138435, MPG1, MPS1, Mpg-1 |
| Other Names | Macrophage-expressed gene 1 protein, Macrophage gene 1 protein, Mpg-1, MPEG1 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-MPEG1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | MPEG1 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MPEG1 {ECO:0000303|PubMed:28422754, ECO:0000312|HGNC:HGNC:29619} |
|---|---|
| Function | Pore-forming protein involved in both innate and adaptive immunity (PubMed:23753625, PubMed:26402460, PubMed:28422754, PubMed:30609079, PubMed:31537793, PubMed:33224153). Plays a central role in antigen cross-presentation in dendritic cells by forming a pore in antigen-containing compartments, thereby promoting delivery of antigens for cross-presentation (By similarity). Also involved in innate immune response following bacterial infection; shows antibacterial activity against a wide spectrum of Gram-positive, Gram- negative and acid-fast bacteria (PubMed:23753625, PubMed:26402460, PubMed:28422754, PubMed:30609079, PubMed:33224153). Reduces the viability of the intracytosolic pathogen L.monocytogenes by inhibiting acidification of the phagocytic vacuole of host cells which restricts bacterial translocation from the vacuole to the cytosol (By similarity). Required for the antibacterial activity of reactive oxygen species and nitric oxide (By similarity). |
| Cellular Location | [Isoform 1]: Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Bacterial infection induces translocation of the cytoplasmic vesicles to bacterium-containing phagocytic vesicles and fusing of the vesicles [Isoform 2]: Secreted |
| Tissue Location | Expressed constitutively in a variety of cell types including macrophages, natural killer cells, neutrophils, keratinocytes and monocytes (PubMed:26402460, PubMed:28705375, PubMed:7888681). In skin, expressed in both hematopoietic and non-hematopoietic cells with expression detected in a variety of cell types including keratinocytes, fibroblasts and endothelial cells (PubMed:30609079) |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Spilsbury K.,et al.Blood 85:1620-1629(1995).
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$ 389.00
Cat# AI13656
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