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FBXO10 antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9UK96 |
| Other Accession | NM_012166, NP_036298 |
| Reactivity | Human, Rat, Horse, Guinea Pig, Dog |
| Predicted | Human, Horse, Guinea Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 105kDa |
| Gene ID | 26267 |
|---|---|
| Alias Symbol | FBX10, FLJ41992, MGC149840, PRMT11 |
| Other Names | F-box only protein 10, FBXO10, FBX10, PRMT11 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-FBXO10 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | FBXO10 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FBXO10 |
|---|---|
| Synonyms | FBX10, PRMT11 |
| Function | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2. Targets also the receptor for advanced glycation end products RAGE for ubiquitination and subsequent lysosomal degradation (PubMed:28515150). Directly controls HGAL/GCSAM ubiquitination and degradation and thereby decreases BCR signaling (PubMed:31570756). |
| Cellular Location | Cytoplasm |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
References
Humphray S.J.,et al.Nature 429:369-374(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Winston J.T.,et al.Curr. Biol. 9:1180-1182(1999).
Cenciarelli C.,et al.Curr. Biol. 9:1177-1179(1999).
Chiorazzi M.,et al.Proc. Natl. Acad. Sci. U.S.A. 110:3943-3948(2013).
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