|Other Accession||NM_012388, NP_036520|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Goat, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Chicken, Goat, Bovine, Guinea Pig, Dog|
|Alias Symbol||PA, PALLID, HPS9, PLDN|
|Other Names||Biogenesis of lysosome-related organelles complex 1 subunit 6, BLOC-1 subunit 6, Pallid protein homolog, Pallidin, Syntaxin 13-interacting protein, BLOC1S6, PA, PLDN|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-PLDN antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||PLDN antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process.|
|Cellular Location||Cytoplasm. Membrane; Peripheral membrane protein. Note=It can exist as a soluble protein as well as a peripheral membrane protein (PubMed:12019270).|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Huang L.,et al.Nat. Genet. 23:329-332(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Falcon-Perez J.M.,et al.Pigment Cell Res. 15:82-86(2002).
Moriyama K.,et al.Traffic 3:666-677(2002).
Falcon-Perez J.M.,et al.J. Biol. Chem. 277:28191-28199(2002).
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