PLDN antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q9UL45 |
Other Accession | NM_012388, NP_036520 |
Reactivity | Human, Mouse, Rat, Rabbit, Pig, Goat, Horse, Bovine, Guinea Pig, Dog |
Predicted | Human, Mouse, Rat, Rabbit, Pig, Chicken, Goat, Bovine, Guinea Pig, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 20kDa |
Gene ID | 26258 |
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Alias Symbol | PA, PALLID, HPS9, PLDN |
Other Names | Biogenesis of lysosome-related organelles complex 1 subunit 6, BLOC-1 subunit 6, Pallid protein homolog, Pallidin, Syntaxin 13-interacting protein, BLOC1S6, PA, PLDN |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-PLDN antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | PLDN antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | BLOC1S6 |
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Synonyms | PA, PLDN |
Function | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process. |
Cellular Location | Cytoplasm. Membrane; Peripheral membrane protein. Note=It can exist as a soluble protein as well as a peripheral membrane protein (PubMed:12019270) |
Tissue Location | Widely expressed. |
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Provided below are standard protocols that you may find useful for product applications.
References
Huang L.,et al.Nat. Genet. 23:329-332(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Falcon-Perez J.M.,et al.Pigment Cell Res. 15:82-86(2002).
Moriyama K.,et al.Traffic 3:666-677(2002).
Falcon-Perez J.M.,et al.J. Biol. Chem. 277:28191-28199(2002).
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