|Other Accession||NM_012388, NP_036520|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Goat, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Chicken, Goat, Bovine, Guinea Pig, Dog|
|Alias Symbol||PA, PALLID, HPS9, PLDN|
|Other Names||Biogenesis of lysosome-related organelles complex 1 subunit 6, BLOC-1 subunit 6, Pallid protein homolog, Pallidin, Syntaxin 13-interacting protein, BLOC1S6, PA, PLDN|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-PLDN antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||PLDN antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process.|
|Cellular Location||Cytoplasm. Membrane; Peripheral membrane protein. Note=It can exist as a soluble protein as well as a peripheral membrane protein (PubMed:12019270).|
|Tissue Location||Widely expressed.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Huang L.,et al.Nat. Genet. 23:329-332(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Falcon-Perez J.M.,et al.Pigment Cell Res. 15:82-86(2002).
Moriyama K.,et al.Traffic 3:666-677(2002).
Falcon-Perez J.M.,et al.J. Biol. Chem. 277:28191-28199(2002).
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.