|Predicted||Human, Mouse, Rat, Pig, Horse, Bovine, Guinea Pig, Dog|
|Other Names||Protein Hook homolog 2, h-hook2, hHK2, HOOK2|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 &mu, l of distilled water. Final Anti-HOOK2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||HOOK2 Antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones.|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cytoplasm, cytoskeleton Note=Colocalizes with aggresomes, which are aggregates of misfolded proteins, at the centrosome. Also localizes to punctate cytoplasmic foci which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, the Golgi complex, multivesicular bodies (MVBs), lysosomes, or mitochondria. Often found in close association with microtubules|
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Provided below are standard protocols that you may find useful for product applications.
Kraemer H.,et al.Genetics 151:675-684(1999).
Grimwood J.,et al.Nature 428:529-535(2004).
Walenta J.H.,et al.J. Cell Biol. 152:923-934(2001).
Szebenyi G.,et al.BMC Cell Biol. 8:19-19(2007).
Szebenyi G.,et al.Traffic 8:32-46(2007).
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