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Agtpbp1 Antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q641K1 |
| Other Accession | NM_023328, NP_075817 |
| Reactivity | Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog |
| Predicted | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 128kDa |
| Gene ID | 67269 |
|---|---|
| Alias Symbol | 1700020N17Rik, 2310001G17Rik, 2900054O13Rik, 4930445M19Rik, 5730402G09Rik, BB114605, CCP1, Nna1, mKIAA1035, nmf243, pcd |
| Other Names | Cytosolic carboxypeptidase 1, 3.4.17.-, ATP/GTP-binding protein 1, Nervous system nuclear protein induced by axotomy protein 1, Agtpbp1, Ccp1, Nna1 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Agtpbp1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Agtpbp1 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Agtpbp1 {ECO:0000312|MGI:MGI:2159437} |
|---|---|
| Function | Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins (PubMed:21074048, PubMed:22170066, PubMed:25103237, PubMed:30420557, PubMed:29593216). Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin (PubMed:22170066, PubMed:25103237, PubMed:30420557). Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate (PubMed:21074048). Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of alpha-tubulin as well as non-tubulin proteins such as MYLK (PubMed:21074048, PubMed:22170066). Involved in KLF4 deglutamylation which promotes KLF4 proteasome-mediated degradation, thereby negatively regulating cell pluripotency maintenance and embryogenesis (PubMed:29593216). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q9UPW5}. Cytoplasm, cytosol. Nucleus. Mitochondrion. Note=Localizes in both the cytoplasm and nuclei of interphase and dividing cells {ECO:0000250|UniProtKB:Q9UPW5} |
| Tissue Location | Widely expressed. Highly expressed in the cerebellum and cortex of adult mouse brain. Expressed at similar levels in both the cerebellum and the cortex throughout all developmental stages. Also expressed in sciatic nerve transection, spinal motor neurons undergoing axon regeneration, testis, heart, eye, lung, pancreas, intestine, stomach, pituitary, spleen, adrenal, kidney and in developing brain. Expression in cranial motor nuclei is the same as that observed in uninjured primary motor neurons. Expression is prevalent in sensory neurons and hippocampal CA3 neurons in addition to regenerating motor neurons. |
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Application Protocols
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$ 389.00
Cat# AI13761
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