|Other Accession||NM_152785, NP_689998|
|Alias Symbol||GCAT2, HGAL, MGC40441, GCET2|
|Other Names||Germinal center-associated signaling and motility protein, Germinal center B-cell-expressed transcript 2 protein, Germinal center-associated lymphoma protein, hGAL, GCSAM, GAL, GCET2|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-GCET2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||GCET2 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation.|
|Cellular Location||Cytoplasm. Cell membrane. Note=It relocalizes from the cytoplasm to podosome-like structures upon cell treatment with IL6|
|Tissue Location||Expressed in diffuse large B-cell lymphoma (DLBCL) and several germinal center (GC)-like lymphoma cell lines (at protein level). Highly expressed in normal GC lymphocytes and GC-derived malignancies. Expressed in thymus and spleen|
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Provided below are standard protocols that you may find useful for product applications.
Pan Z.,et al.Am. J. Pathol. 163:135-144(2003).
Lossos I.S.,et al.Blood 101:433-440(2003).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Natkunam Y.,et al.Blood 105:3979-3986(2005).
Lu X.,et al.Blood 110:4268-4277(2007).
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