ZDHHC21 antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
---|---|
Primary Accession | Q5RB84 |
Other Accession | NM_178566, NP_848661 |
Reactivity | Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog |
Predicted | Rat, Rabbit, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 31kDa |
Gene ID | 100172477 |
---|---|
Alias Symbol | DNZ1, DHHC-21, HSPC097, 9130404H11Rik |
Other Names | Probable palmitoyltransferase ZDHHC21, 2.3.1.225, Zinc finger DHHC domain-containing protein 21, DHHC-21, ZDHHC21 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-ZDHHC21 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | ZDHHC21 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ZDHHC21 {ECO:0000250|UniProtKB:Q8IVQ6} |
---|---|
Function | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (By similarity). Palmitoylates FYN, regulates its localization in hair follicles and plays a key role in epidermal homeostasis and hair follicle differentiation. Through the palmitoylation of PLCB1 and the regulation of PLCB1 downstream signaling may indirectly regulate the function of the endothelial barrier and the adhesion of leukocytes to the endothelium. Has also a palmitoyltransferase activity toward ADRA1D, positively regulating its activity and expression and may thereby play a role in vascular contraction. May also palmitoylate eNOS and LCK (By similarity). |
Cellular Location | Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8IVQ6}; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:Q9D270}; Multi-pass membrane protein. Cell membrane {ECO:0000250|UniProtKB:Q8IVQ6}; Multi-pass membrane protein |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.