|Application ||WB, IHC|
|Other Accession||NM_006003, NP_008846|
|Reactivity||Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rabbit, Horse, Bovine, Dog|
|Alias Symbol||KIAA0215, TBCCD2, XRP2, NME10, DELXp11.3|
|Other Names||Protein XRP2, RP2|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-RP2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||RP2 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium membrane by inducing hydrolysis of GTP ARL3, leading to the release of UNC119 (or UNC119B). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. Acts as guanine nucleotide dissociation inhibitor towards ADP-ribosylation factor-like proteins.|
|Cellular Location||Cell membrane; Lipid-anchor; Cytoplasmic side. Cell projection, cilium. Note=Detected predominantly to the plasma membrane of rod and cone photoreceptors. Not detected in the nucleus|
|Tissue Location||Ubiquitous. Expressed in the rod and cone photoreceptors, extending from the tips of the outer segment (OS) through the inner segment (IS) and outer nuclear layer (ONL) and into the synaptic terminals of the outer plexiform layer (ONL) Also detected in the bipolar, horizontal and amacrine cells in the inner nuclear layer (INL), extending to the inner plexiform layer (IPL) and though the ganglion cell layer (GCL) and into the nerve fiber layer (NFL) (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
Schwahn U.,et al.Nat. Genet. 19:327-332(1998).
Ross M.T.,et al.Nature 434:325-337(2005).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
Chapple J.P.,et al.Hum. Mol. Genet. 9:1919-1926(2000).
Bartolini F.,et al.J. Biol. Chem. 277:14629-14634(2002).
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