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>   home   >   Products   >   Primary Antibodies   >   Cops4 antibody - N-terminal region   

Cops4 antibody - N-terminal region

Rabbit Polyclonal Antibody

  • WB - Cops4 antibody - N-terminal region AI14014

    WB Suggested Anti-Cops4 Antibody Titration: 1.0 μg/ml
    Positive Control: Rat Lung
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q68FS2
Other Accession NM_001004275.1, CAAW13HP01P
Reactivity Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Chicken, Horse, Guinea Pig
Host Rabbit
Clonality Polyclonal
Calculated MW 44kDa
Additional Information
Gene ID 360915
Alias Symbol MGC94896
Other Names COP9 signalosome complex subunit 4, SGN4, Signalosome subunit 4, JAB1-containing signalosome subunit 4, Cops4, Csn4
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Cops4 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsCops4 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Cops4
Synonyms Csn4
Function Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity).
Cellular Location Cytoplasm. Nucleus. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle
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Granata A.,et al.EMBO J. 30:181-193(2011).

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$ 293.00
Cat# AI14014
(40 western blots)
Availability: 2-3 days
Bulk Size
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