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Rab23 antibody - middle region

Rabbit Polyclonal Antibody

  • WB - Rab23 antibody - middle region AI14021

    WB Suggested Anti-Rab23 Antibody Titration: 1.0 μg/ml
    Positive Control: Mouse Brain
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P35288
Other Accession NM_008999, NP_033025
Reactivity Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Rat, Chicken, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 26kDa
Additional Information
Alias Symbol AW545388, opb, opb2
Other Names Ras-related protein Rab-23, Protein open brain, Rab-15, Rab23, Opb
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Rab23 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsRab23 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Rab23
Synonyms Opb
Function The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes (By similarity). Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity.
Cellular Location Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm. Cell membrane. Endosome membrane. Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to phagosomes containing S.aureus or Mycobacterium.
Tissue Location Detected in brain neurons (at protein level). Forebrain and midbrain.
Research Areas
Citations (0)

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Olkkonen V.M.,et al.Gene 138:207-211(1994).
Chavrier P.,et al.Gene 112:261-264(1992).
Gunther T.,et al.Development 120:3119-3130(1994).
Eggenschwiler J.T.,et al.Dev. Biol. 227:648-660(2000).
Eggenschwiler J.T.,et al.Nature 412:194-198(2001).

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$ 293.00
Cat# AI14021
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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