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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   CRBN antibody - N-terminal region   

CRBN antibody - N-terminal region

Rabbit Polyclonal Antibody

  • WB - CRBN antibody - N-terminal region AI14025

    WB Suggested Anti-CRBN Antibody Titration: 0.2-1 μg/ml
    Positive Control: COLO205 cell lysate
  • WB - CRBN antibody - N-terminal region AI14025

    Host: Rabbit
    Target Name: CRBN
    Sample Tissue: RPMI-8226 Whole Cell lysates
    Antibody Dilution: 0.5μg/ml
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96SW2
Other Accession NM_016302, NP_057386
Reactivity Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig
Predicted Human, Mouse, Rat, Rabbit, Pig, Chicken, Horse, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 50kDa
Additional Information
Gene ID 51185
Alias Symbol DKFZp781K0715, MGC27358, MRT2A, MRT2
Other Names Protein cereblon, CRBN
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-CRBN antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsCRBN antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Substrate recognition component of a DCX (DDB1-CUL4-X- box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding of pomalidomide and other thalidomide-related drugs changes the substrate specificity of the human protein, leading to decreased degradation of MEIS2 and other target proteins and increased degradation of MYC, IRF4, IKZF1 and IKZF3.
Cellular Location Cytoplasm. Nucleus. Membrane; Peripheral membrane protein
Tissue Location Widely expressed. Highly expressed in brain.
Research Areas
Citations (0)

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Ota T.,et al.Nat. Genet. 36:40-45(2004).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Hu R.-M.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Higgins J.J.,et al.Neurology 63:1927-1931(2004).

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$ 293.00
Cat# AI14025
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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