CCDC25 antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q86WR0 |
Other Accession | NM_018246, NP_060716 |
Reactivity | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Dog |
Predicted | Human, Mouse, Rat, Rabbit, Horse |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 24kDa |
Gene ID | 55246 |
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Alias Symbol | FLJ10853 |
Other Names | Coiled-coil domain-containing protein 25, CCDC25 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-CCDC25 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | CCDC25 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CCDC25 {ECO:0000303|PubMed:32528174, ECO:0000312|HGNC:HGNC:25591} |
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Function | Transmembrane receptor that senses neutrophil extracellular traps (NETs) and triggers the ILK-PARVB pathway to enhance cell motility (PubMed:32528174). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (PubMed:32528174). Formation of NETs is also associated with cancer metastasis, NET-DNA acting as a chemotactic factor to attract cancer cells (PubMed:32528174). Specifically binds NETs on its extracellular region, in particular the 8-OHdG-enriched DNA present in NETs, and recruits ILK, initiating the ILK-PARVB cascade to induce cytoskeleton rearrangement and directional migration of cells (PubMed:32528174). In the context of cancer, promotes cancer metastasis by sensing NETs and promoting migration of tumor cells (PubMed:32528174). |
Cellular Location | Cell membrane; Single-pass membrane protein Endomembrane system. Note=Localizes to cytoplasmic membrane in tumor cells. |
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Provided below are standard protocols that you may find useful for product applications.
References
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nusbaum C.,et al.Nature 439:331-335(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Olsen J.V.,et al.Cell 127:635-648(2006).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
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