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Pi4k2b antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q8CBQ5 |
| Other Accession | NM_025951, NP_080227 |
| Reactivity | Human, Mouse, Rat, Rabbit, Horse, Yeast, Bovine, Guinea Pig, Dog |
| Predicted | Human, Rabbit, Chicken, Horse, Bovine, Guinea Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 52kDa |
| Gene ID | 67073 |
|---|---|
| Alias Symbol | 2610042N09Rik, 4933409G22Rik |
| Other Names | Phosphatidylinositol 4-kinase type 2-beta, 2.7.1.67, Phosphatidylinositol 4-kinase type II-beta, Pi4k2b |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Pi4k2b antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Pi4k2b antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Pi4k2b |
|---|---|
| Function | Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking. |
| Cellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8TCG2}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8TCG2}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8TCG2}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8TCG2}. Cell membrane {ECO:0000250|UniProtKB:Q8TCG2}. Early endosome membrane {ECO:0000250|UniProtKB:Q8TCG2}. Note=Mainly cytosolic, association with membranes of the Golgi, endoplasmic and plasma membrane is stimulated by active RAC1. Association with early endosomes has not been confirmed. {ECO:0000250|UniProtKB:Q8TCG2} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Hong W.,et al.Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
Li W.,et al.Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases.
Carninci P.,et al.Science 309:1559-1563(2005).
Trost M.,et al.Immunity 30:143-154(2009).
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