|Other Accession||NM_025951, NP_080227|
|Reactivity||Human, Mouse, Rat, Rabbit, Horse, Yeast, Bovine, Guinea Pig, Dog|
|Predicted||Human, Rabbit, Chicken, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||2610042N09Rik, 4933409G22Rik|
|Other Names||Phosphatidylinositol 4-kinase type 2-beta, 22.214.171.124, Phosphatidylinositol 4-kinase type II-beta, Pi4k2b|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Pi4k2b antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Pi4k2b antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking (By similarity).|
|Cellular Location||Cytoplasm. Membrane. Note=Mostly cytoplasmic but also found associated with the plasma membrane, the Golgi and endosomes. Compared to PI4K2A, a larger fraction of PI4K2B is cytosolic due to a smaller extent of palmitoylation. Translocates to membranes where it is recruited by PDGF stimulation by a Rac-GTP-dependent mechanism (By similarity).|
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Hong W.,et al.Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
Li W.,et al.Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases.
Carninci P.,et al.Science 309:1559-1563(2005).
Trost M.,et al.Immunity 30:143-154(2009).
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