TBC1D24 antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q9ULP9 |
Other Accession | NM_020705, NP_065756 |
Reactivity | Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog |
Predicted | Human, Rat, Rabbit, Chicken, Horse, Guinea Pig |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 62kDa |
Gene ID | 57465 |
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Alias Symbol | KIAA1171, MGC102885, FIME |
Other Names | TBC1 domain family member 24, TBC1D24, KIAA1171 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-TBC1D24 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | TBC1D24 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TBC1D24 |
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Synonyms | KIAA1171 |
Function | May act as a GTPase-activating protein for Rab family protein(s) (PubMed:20727515, PubMed:20797691). Involved in neuronal projections development, probably through a negative modulation of ARF6 function (PubMed:20727515). Involved in the regulation of synaptic vesicle trafficking (PubMed:31257402). |
Cellular Location | Cell membrane; Peripheral membrane protein. Cytoplasm. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9VIH7}. Presynapse. Note=Mainly cytoplasmatic with partial expression at the plasma membrane (PubMed:20727515). Associates with certain types of membrane phosphoinositides, preferentially those phosphorylated at the D5 position of the inositol ring such as phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3) (By similarity) {ECO:0000250|UniProtKB:Q9VIH7, ECO:0000269|PubMed:20727515} |
Tissue Location | Highest expression in brain. |
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Provided below are standard protocols that you may find useful for product applications.
References
Hirosawa M.,et al.DNA Res. 6:329-336(1999).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Ishibashi K.,et al.Genes Cells 14:41-52(2009).
Falace A.,et al.Am. J. Hum. Genet. 87:365-370(2010).
Corbett M.A.,et al.Am. J. Hum. Genet. 87:371-375(2010).
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