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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Dennd1a antibody - C-terminal region   

Dennd1a antibody - C-terminal region

Rabbit Polyclonal Antibody

     
  • WB - Dennd1a antibody - C-terminal region AI14131

    WB Suggested Anti-Dennd1a Antibody Titration: 1.0 μg/ml
    Positive Control: Mouse Heart
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q8K382
Other Accession NM_146122, NP_666234
Reactivity Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 111kDa
Additional Information
Gene ID 227801
Alias Symbol 6030446I19Rik, MGC38995, connecdenn
Other Names DENN domain-containing protein 1A, Connecdenn 1, Connecdenn, Dennd1a
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Dennd1a antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsDennd1a antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Dennd1a
Function Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:17182770, PubMed:20159556). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (PubMed:20159556).
Cellular Location Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein. Cell junction, synapse, presynaptic cell membrane. Note=Associates to membranes via lipid-binding activity.
Research Areas
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References

Allaire P.D.,et al.J. Neurosci. 26:13202-13212(2006).
Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).
Trost M.,et al.Immunity 30:143-154(2009).

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$ 293.00
Cat# AI14131
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