Dennd1a antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q8K382 |
Other Accession | NM_146122, NP_666234 |
Reactivity | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog |
Predicted | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 111kDa |
Gene ID | 227801 |
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Alias Symbol | 6030446I19Rik, MGC38995, connecdenn |
Other Names | DENN domain-containing protein 1A, Connecdenn 1, Connecdenn, Dennd1a |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Dennd1a antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | Dennd1a antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Dennd1a |
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Function | Guanine nucleotide exchange factor (GEF) regulating clathrin- mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP- bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:17182770, PubMed:20159556). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (PubMed:20159556). |
Cellular Location | Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein. Presynaptic cell membrane. Note=Associates to membranes via lipid- binding activity. |
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Provided below are standard protocols that you may find useful for product applications.
References
Allaire P.D.,et al.J. Neurosci. 26:13202-13212(2006).
Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).
Trost M.,et al.Immunity 30:143-154(2009).
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