|Other Accession||NM_033540, NP_284941|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Chicken, Horse, Bovine, Dog|
|Calculated MW||84 KDa|
|Alias Symbol||DKFZp762F247, FLJ20693, MGC41806, hfzo1, hfzo2|
|Other Names||Mitofusin-1, 3.6.5.-, Mitochondrial transmembrane GTPase FZO1B, Transmembrane GTPase MFN1, Mfn1, Fzo1b|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-MFN1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||MFN1 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks.|
|Cellular Location||Mitochondrion outer membrane; Multi-pass membrane protein|
|Tissue Location||Ubiquitous. In brain, it is expressed at weaker level than MFN2, while it is expressed at a higher level than MFN2 in heart and testis. Expressed at high level in elongating spermatids of seminiferous tubules|
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Provided below are standard protocols that you may find useful for product applications.
Eura Y.,et al.J. Biochem. 134:333-344(2003).
Ishihara N.,et al.Biochem. Biophys. Res. Commun. 301:891-898(2003).
Honda S.,et al.Biochem. Biophys. Res. Commun. 311:424-432(2003).
Eura Y.,et al.J. Cell Sci. 119:4913-4925(2006).
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