|Reactivity||Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Other Names||E3 ubiquitin-protein ligase RNF216, 6.3.2.-, RING finger protein 216, Triad domain-containing protein 3, UbcM4-interacting protein 83, Ubiquitin-conjugating enzyme 7-interacting protein 1, Rnf216, Triad3, Ubce7ip1, Uip83, Zin|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Rnf216 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Rnf216 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||Triad3, Ubce7ip1, Uip83, Zin|
|Function||Acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Promotes degradation of TRAF3, TLR4 and TLR9. Contributes to the regulation of antiviral responses. Down-regulates activation of NF-kappa-B, IRF3 activation and IFNB production. Promotes TNF and RIP mediated apoptosis (By similarity).|
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Chuang T.H.,et al.Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
Carninci P.,et al.Science 309:1559-1563(2005).
Martinez-Noel G.,et al.FEBS Lett. 454:257-261(1999).
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