|Other Accession||NM_053814, NP_446266|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||M-rip, Mrip, Rhoip3, p116Rip|
|Other Names||Myosin phosphatase Rho-interacting protein, Rho-interacting protein 3, RIP3, p116Rip, Mprip, Mrip, Rhoip3|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Mprip antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Mprip Antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F- actin-binding region leads to disassembly of stress fibers in neuronal cells (By similarity).|
|Cellular Location||Cytoplasm, cytoskeleton. Note=Colocalizes with F-actin.|
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Lanson N.A. Jr.,et al.Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
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