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Trim3 antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9R1R2 |
| Other Accession | NM_018880, NP_061368 |
| Reactivity | Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog |
| Predicted | Human, Mouse, Rat, Pig, Horse, Bovine, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 81kDa |
| Gene ID | 55992 |
|---|---|
| Alias Symbol | BERP1, HAC1, Rnf22 |
| Other Names | Tripartite motif-containing protein 3, RING finger protein 22, RING finger protein HAC1, Trim3, Hac1, Rnf22 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Trim3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Trim3 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Trim3 |
|---|---|
| Synonyms | Hac1, Rnf22 |
| Function | E3 ubiquitin ligase that plays essential roles in neuronal functions such as regulation of neuronal plasticity, learning, and memory (PubMed:24086586, PubMed:26527743). In addition to its neuronal functions, participates in other biological processes such as innate immunity or cell cycle regulation (By similarity). Component of the cytoskeleton-associated recycling or transport complex in neurons, polyubiquitinates gamma-actin, thus regulating neuronal plasticity, learning, and memory (PubMed:26527743). Ubiquitinates postsynaptic scaffold GKAP, a neuronal substrate involved in synaptic remodeling and thereby modulates dendritic spine morphology (By similarity). Positively regulates motility of microtubule-dependent motor protein KIF21B (PubMed:24086586). Induces growth arrest via its RING-dependent E3 ligase activity and ubiquinates CDKN1A. Positively regulates TLR3- mediated signaling by mediating 'Lys-63'-linked polyubiquitination of TLR3 (PubMed:26527743). In turn, promotes the recognition and sorting of polyubiquitinated TLR3 by the ESCRT complexes (By similarity). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:O75382}. Early endosome {ECO:0000250|UniProtKB:O75382}. Golgi apparatus, trans-Golgi network. Cell projection, dendrite. Note=Mainly located in the Golgi apparatus and transported to the early endosomes upon stimulation with dsRNA. {ECO:0000250|UniProtKB:O75382} |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Yanai K.,et al.Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
Reymond A.,et al.EMBO J. 20:2140-2151(2001).
Carninci P.,et al.Science 309:1559-1563(2005).
Trinidad J.C.,et al.Mol. Cell. Proteomics 5:914-922(2006).
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$ 389.00
Cat# AI14226
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