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Lynx1 antibody - middle region

Rabbit Polyclonal Antibody

  • WB - Lynx1 antibody - middle region AI14320

    WB Suggested Anti-Lynx1 Antibody Titration: 1.0 μg/ml
    Positive Control: Mouse Heart
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9WVC2
Other Accession NM_011838, NP_035968
Reactivity Human, Mouse, Rat, Bovine, Guinea Pig
Predicted Human, Mouse, Rat, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 13kDa
Additional Information
Gene ID 23936;69462
Alias Symbol AI838844
Other Names Ly-6/neurotoxin-like protein 1, GC26, Secreted Ly-6/uPAR domain-containing protein 2, Secreted Ly-6/uPAR-related protein 2, SLURP-2, Lynx1, Slurp2
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Lynx1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsLynx1 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Lynx1
Synonyms Slurp2
Function Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). Isoform 2 modulates functional properties of nicotinic acetylcholine receptors (nAChRs) to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and extent of desensitization of alpha(4)beta(2) nAChRs and slowing recovery from desensitization. Promotes large amplitude ACh-evoked currents through alpha(4)beta(2) nAChRs. Prevents plasticity in the primary visual cortex late in life. In keratinocytes, isoform 3 delays differentiation and prevents apoptosis (By similarity).
Cellular Location Isoform 1: Secreted. Isoform 3: Secreted.
Tissue Location Isoform 2 is expressed in neurons of multiple regions in the CNS, including the cerebral cortex, thalamus, substantia nigra, cerebellum, amygdala and hippocampus. Also expressed in kidney, heart and thymus, but at lower levels than in the brain. Expressed in the primary visual cortex (V1) and the lateral geniculate nucleus (at protein level). Isoform 3 is widely expressed, including in dendritic cells, macrophages, B- and T- lymphocytes.
Research Areas
Citations (0)

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Miwa J.M.,et al.Neuron 23:105-114(1999).
Moriwaki Y.,et al.Life Sci. 80:2365-2368(2007).
Miwa J.M.,et al.Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
Carninci P.,et al.Science 309:1559-1563(2005).
Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).

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$ 293.00
Cat# AI14320
Availability: 2-3 days
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