|Other Accession||NM_011838, NP_035968|
|Reactivity||Human, Mouse, Rat, Bovine, Guinea Pig|
|Predicted||Human, Mouse, Rat, Bovine|
|Other Names||Ly-6/neurotoxin-like protein 1, GC26, Secreted Ly-6/uPAR domain-containing protein 2, Secreted Ly-6/uPAR-related protein 2, SLURP-2, Lynx1, Slurp2|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Lynx1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Lynx1 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). Isoform 2 modulates functional properties of nicotinic acetylcholine receptors (nAChRs) to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and extent of desensitization of alpha(4)beta(2) nAChRs and slowing recovery from desensitization. Promotes large amplitude ACh-evoked currents through alpha(4)beta(2) nAChRs. Prevents plasticity in the primary visual cortex late in life. In keratinocytes, isoform 3 delays differentiation and prevents apoptosis (By similarity).|
|Cellular Location||Isoform 1: Secreted. Isoform 3: Secreted.|
|Tissue Location||Isoform 2 is expressed in neurons of multiple regions in the CNS, including the cerebral cortex, thalamus, substantia nigra, cerebellum, amygdala and hippocampus. Also expressed in kidney, heart and thymus, but at lower levels than in the brain. Expressed in the primary visual cortex (V1) and the lateral geniculate nucleus (at protein level). Isoform 3 is widely expressed, including in dendritic cells, macrophages, B- and T- lymphocytes.|
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Provided below are standard protocols that you may find useful for product applications.
Miwa J.M.,et al.Neuron 23:105-114(1999).
Moriwaki Y.,et al.Life Sci. 80:2365-2368(2007).
Miwa J.M.,et al.Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
Carninci P.,et al.Science 309:1559-1563(2005).
Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).
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