|Other Accession||NM_133687, NP_598448|
|Reactivity||Human, Mouse, Rat, Horse, Guinea Pig|
|Predicted||Human, Mouse, Rat, Pig, Horse, Guinea Pig|
|Other Names||CXXC-type zinc finger protein 5, Cxxc5|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Cxxc5 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Cxxc5 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May indirectly participate in activation of the NF- kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells. Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis (By similarity). Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (By similarity).|
|Cellular Location||Nucleus. Cytoplasm. Note=Colocalizes with DVL1 in large bodies localized just outside the nuclear membrane.|
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Carninci P.,et al.Science 309:1559-1563(2005).
Andersson T.,et al.J. Biol. Chem. 284:3672-3681(2009).
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