|Other Accession||NM_133687, NP_598448|
|Reactivity||Human, Mouse, Rat, Horse, Guinea Pig|
|Predicted||Human, Mouse, Rat, Pig, Horse, Guinea Pig|
|Other Names||CXXC-type zinc finger protein 5, Cxxc5|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Cxxc5 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Cxxc5 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May indirectly participate in activation of the NF- kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells. Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis (By similarity). Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (By similarity).|
|Cellular Location||Nucleus. Cytoplasm. Note=Colocalizes with DVL1 in large bodies localized just outside the nuclear membrane.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Carninci P.,et al.Science 309:1559-1563(2005).
Andersson T.,et al.J. Biol. Chem. 284:3672-3681(2009).
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.