|Other Accession||NM_138507, NP_612516|
|Reactivity||Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig|
|Alias Symbol||CD45, L-CA, Lca, RT7, T200|
|Other Names||Receptor-type tyrosine-protein phosphatase C, 220.127.116.11, Leukocyte common antigen, L-CA, T200, CD45, Ptprc|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Ptprc antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Ptprc Antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).|
|Cellular Location||Membrane; Single-pass type I membrane protein. Membrane raft Note=Colocalized with DPP4 in membrane rafts.|
|Tissue Location||Isoform 1 and isoform 2 are found in thymocyte and lymph node. Isoform 4 and isoform 3 are found in the lymph nod|
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Barclay A.N.,et al.EMBO J. 6:1259-1264(1987).
Barclay A.N.,et al.Submitted (MAY-1987) to the EMBL/GenBank/DDBJ databases.
Thomas M.L.,et al.Cell 41:83-93(1985).
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