|Other Accession||NM_138507, NP_612516|
|Reactivity||Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig|
|Alias Symbol||CD45, L-CA, Lca, RT7, T200|
|Other Names||Receptor-type tyrosine-protein phosphatase C, 188.8.131.52, Leukocyte common antigen, L-CA, T200, CD45, Ptprc|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Ptprc antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Ptprc Antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).|
|Cellular Location||Membrane; Single-pass type I membrane protein. Membrane raft Note=Colocalized with DPP4 in membrane rafts.|
|Tissue Location||Isoform 1 and isoform 2 are found in thymocyte and lymph node. Isoform 4 and isoform 3 are found in the lymph nod|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Barclay A.N.,et al.EMBO J. 6:1259-1264(1987).
Barclay A.N.,et al.Submitted (MAY-1987) to the EMBL/GenBank/DDBJ databases.
Thomas M.L.,et al.Cell 41:83-93(1985).
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.