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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Arhgef4 Antibody - N-terminal region   

Arhgef4 Antibody - N-terminal region

Rabbit Polyclonal Antibody

  • WB - Arhgef4 Antibody - N-terminal region AI14374

    Host: Rabbit
    Target Name: Arhgef4
    Sample Tissue: Mouse Testis lysates
    Antibody Dilution: 1.0μg/ml
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q7TNR9
Other Accession NM_183019, NP_898840
Reactivity Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 57kDa
Additional Information
Gene ID 226970
Alias Symbol 9330140K16Rik, Asef, ENSMUSG00000070955
Other Names Rho guanine nucleotide exchange factor 4, APC-stimulated guanine nucleotide exchange factor, Asef, Arhgef4, Kiaa1112
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Arhgef4 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsArhgef4 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Arhgef4
Synonyms Kiaa1112
Function Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion (By similarity). Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.
Cellular Location Cytoplasm. Note=Colocalized with APC in the synapse of olfactory glomerulus
Tissue Location Expressed in colon epithelial cells. Highly expressed in CNS, including hippocampus, olfactory bulb and cerebellum. Expression is aberrantly enhanced in most colorectal tumors.
Research Areas
Citations (0)

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Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).
Okazaki N.,et al.DNA Res. 10:35-48(2003).
Okazaki N.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Kawasaki Y.,et al.Science 289:1194-1197(2000).
Kawasaki Y.,et al.EMBO Rep. 10:1355-1362(2009).

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$ 293.00
Cat# AI14374
(40 western blots)
Availability: 2-3 days
Bulk Size
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