|Other Accession||NM_183019, NP_898840|
|Reactivity||Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||9330140K16Rik, Asef, ENSMUSG00000070955|
|Other Names||Rho guanine nucleotide exchange factor 4, APC-stimulated guanine nucleotide exchange factor, Asef, Arhgef4, Kiaa1112|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Arhgef4 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Arhgef4 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion (By similarity). Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.|
|Cellular Location||Cytoplasm. Note=Colocalized with APC in the synapse of olfactory glomerulus|
|Tissue Location||Expressed in colon epithelial cells. Highly expressed in CNS, including hippocampus, olfactory bulb and cerebellum. Expression is aberrantly enhanced in most colorectal tumors.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).
Okazaki N.,et al.DNA Res. 10:35-48(2003).
Okazaki N.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Kawasaki Y.,et al.Science 289:1194-1197(2000).
Kawasaki Y.,et al.EMBO Rep. 10:1355-1362(2009).
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