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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Rassf5 Antibody - C-terminal region   

Rassf5 Antibody - C-terminal region

Rabbit Polyclonal Antibody

  • WB - Rassf5 Antibody - C-terminal region AI14436

    Host: Rabbit
    Target Name: Rassf5
    Sample Tissue: Mouse Spleen lysates
    Antibody Dilution: 1.0μg/ml
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q5EBH1
Other Accession NM_018750, NP_061220
Reactivity Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 47kDa
Additional Information
Gene ID 54354
Alias Symbol 1300019G20Rik, AU042887, Maxp1, Nore1, Nore1A, Nore1B, Rapl
Other Names Ras association domain-containing protein 5, New ras effector 1, Regulator for cell adhesion and polarization enriched in lymphoid tissues, RAPL, Rassf5, Nore1, Rapl
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Rassf5 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsRassf5 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Rassf5
Synonyms Nore1, Rapl
Function Potental tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing (By similarity). May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis.
Cellular Location Cytoplasm. Cytoplasm, cytoskeleton. Note=Isoform 2 is mainly located in the perinuclear region of unstimulated primary T-cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A (By similarity).
Research Areas
Citations (0)

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Vavvas D.,et al.J. Biol. Chem. 273:5439-5442(1998).
Katagiri K.,et al.Nat. Immunol. 4:741-748(2003).
Okazaki N.,et al.DNA Res. 11:127-135(2004).
Carninci P.,et al.Science 309:1559-1563(2005).
Khokhlatchev A.,et al.Curr. Biol. 12:253-265(2002).

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$ 293.00
Cat# AI14436
(40 western blots)
Availability: 2-3 days
Bulk Size
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