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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   ADAM17 Antibody - C-terminal region   

ADAM17 Antibody - C-terminal region

Rabbit Polyclonal Antibody

  • WB - ADAM17 Antibody - C-terminal region AI14653

    Host: Rabbit
    Target Name: ADAM17
    Sample Tissue: 786-0 Whole cell lysate
    Antibody Dilution: 1.0μg/ml
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P78536
Other Accession NP_003174
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 90kDa
Additional Information
Gene ID 6868
Alias Symbol ADAM17, CSVP, TACE,
Other Names Disintegrin and metalloproteinase domain-containing protein 17, ADAM 17,, Snake venom-like protease, TNF-alpha convertase, TNF-alpha-converting enzyme, CD156b, ADAM17, CSVP, TACE
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 &mu, l of distilled water. Final Anti-ADAM17 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
PrecautionsADAM17 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ADAM17
Synonyms CSVP, TACE
Function Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney
Research Areas
Citations (0)

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Moss M.L.,et al.Nature 385:733-736(1997).
Black R.A.,et al.Nature 385:729-733(1997).
Patel I.R.,et al.J. Immunol. 160:4570-4579(1998).
Diaz-Rodriguez E.,et al.Mol. Biol. Cell 13:2031-2044(2002).
Thathiah A.,et al.J. Biol. Chem. 278:3386-3394(2003).

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$ 293.00
Cat# AI14653
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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