|Other Accession||NM_021004, NP_066284|
|Reactivity||Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Bovine, Dog|
|Alias Symbol||FLJ11008, NRDR, SCAD-SRL, SDR-SRL, SDR25C1|
|Other Names||Dehydrogenase/reductase SDR family member 4, 188.8.131.52, NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase, CR, PHCR, NADPH-dependent retinol dehydrogenase/reductase, NRDR, humNRDR, Peroxisomal short-chain alcohol dehydrogenase, PSCD, SCAD-SRL, Short-chain dehydrogenase/reductase family member 4, DHRS4|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-DHRS4 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||DHRS4 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co- factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity).|
|Cellular Location||Peroxisome. Note=Isoform 1 is peroxisomal, while isoform 4 is not|
|Tissue Location||Isoform 1 is predominantly expressed in normal cervix (at protein level). Isoform 4 is expressed in some neoplastic cervical tissues, but not in normal cervix (at protein level). Isoform 5 and isoform 6 are expressed in a few neoplastic cervical tissues|
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Fransen M.,et al.Biochem. J. 340:561-568(1999).
Furukawa A.,et al.Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
Du J.,et al.Yi Chuan Xue Bao 31:661-667(2004).
Tu Q.,et al.Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
Li Y.F.,et al.Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
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