SIRPG antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | O75131 |
Other Accession | NM_003909, NP_003900 |
Reactivity | Human, Horse, Bovine |
Predicted | Human, Bovine |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 27kDa |
Gene ID | 8895 |
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Alias Symbol | CD172g, FLJ42230, SIRP-B2, SIRPB2, SIRPgamma, bA77C3.1 |
Other Names | Copine-3, Copine III, CPNE3, CPN3, KIAA0636 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-SIRPG antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | SIRPG antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CPNE3 (HGNC:2316) |
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Function | Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation (PubMed:20010870). |
Cellular Location | Nucleus. Cytoplasm. Cell membrane Cell junction. Cell junction, focal adhesion. Note=Associates to the membrane in a calcium-dependent manner (PubMed:20010870). Translocates to the cell membrane and the nucleus in a calcium- or growth factor heregulin- dependent manner (PubMed:21087455, PubMed:20010870). Colocalizes with the tyrosine phosphorylated ERBB2 form at cell membrane and focal adhesions in a calcium- or growth factor heregulin-dependent manner (PubMed:20010870). |
Tissue Location | Expressed in breast and weakly in prostate and ovarian tissues (PubMed:20010870). Expressed in neutrophils (at protein level) (PubMed:12949241). Widely expressed (PubMed:11041869). Expressed in the brain. Expressed in neutrophil precursors from the bone marrow and peripheral blood (PubMed:12949241). Expressed in primary breast tumors and ovarian endometrioid adenocarcinoma (PubMed:20010870) |
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Provided below are standard protocols that you may find useful for product applications.
References
Caudell E.G.,et al.Biochemistry 39:13034-13043(2000).
Ishikawa K.,et al.DNA Res. 5:169-176(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
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