|Other Accession||NM_003909, NP_003900|
|Reactivity||Human, Horse, Bovine|
|Alias Symbol||CD172g, FLJ42230, SIRP-B2, SIRPB2, SIRPgamma, bA77C3.1|
|Other Names||Copine-3, Copine III, CPNE3, CPN3, KIAA0636|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-SIRPG antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||SIRPG antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation (PubMed:20010870).|
|Cellular Location||Nucleus. Cytoplasm. Cell membrane. Cell junction. Cell junction, focal adhesion. Note=Associates to the membrane in a calcium-dependent manner (PubMed:20010870) Translocates to the cell membrane and the nucleus in a calcium- or growth factor heregulin-dependent manner (PubMed:21087455, PubMed:20010870). Colocalizes with the tyrosine phosphorylated ERBB2 form at cell membrane and focal adhesions in a calcium- or growth factor heregulin-dependent manner (PubMed:20010870)|
|Tissue Location||Expressed in breast and weakly in prostate and ovarian tissues (PubMed:20010870). Expressed in neutrophils (at protein level) (PubMed:12949241). Widely expressed (PubMed:11041869). Expressed in the brain. Expressed in neutrophil precursors from the bone marrow and peripheral blood (PubMed:12949241). Expressed in primary breast tumors and ovarian endometrioid adenocarcinoma (PubMed:20010870)|
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Provided below are standard protocols that you may find useful for product applications.
Caudell E.G.,et al.Biochemistry 39:13034-13043(2000).
Ishikawa K.,et al.DNA Res. 5:169-176(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
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