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GPR52 antibody - C-terminal region

Rabbit Polyclonal Antibody

     
  • WB - GPR52 antibody - C-terminal region AI14870

    WB Suggested Anti-GPR52 Antibody Titration: 1.0 μg/ml
    Positive Control: Fetal Heart
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q9Y2T5
Other Accession NM_005684, NP_005675
Reactivity Human, Mouse, Rat, Pig, Bovine, Guinea Pig
Predicted Human, Mouse, Bovine, Guinea Pig
Host Rabbit
Clonality Polyclonal
Calculated MW 40kDa
Additional Information
Gene ID 9293
Alias Symbol MGC111751
Other Names Probable G-protein coupled receptor 52, GPR52
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-GPR52 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsGPR52 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GPR52 {ECO:0000303|PubMed:9931487, ECO:0000312|HGNC:HGNC:4508}
Function Gs-coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization (PubMed:24587241). May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum (PubMed:24587241). Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation (PubMed:25738228).
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Expressed in brain, especially in striatum.
Research Areas
Citations (0)
citation

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References

Sawzdargo M.,et al.Brain Res. Mol. Brain Res. 64:193-198(1999).
Gregory S.G.,et al.Nature 441:315-321(2006).

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$ 389.00
Cat# AI14870
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