|Other Accession||NM_002775, NP_002766|
|Reactivity||Human, Mouse, Rat, Pig, Bovine|
|Predicted||Human, Mouse, Rat, Pig, Bovine|
|Alias Symbol||ARMD7, HtrA, L56, ORF480, PRSS11|
|Other Names||Serine protease HTRA1, 3.4.21.-, High-temperature requirement A serine peptidase 1, L56, Serine protease 11, HTRA1, HTRA, PRSS11|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-HTRA1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||HTRA1 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.|
|Cellular Location||Cell membrane. Secreted. Cytoplasm, cytosol Note=Predominantly secreted (PubMed:15208355). Also found associated with the plasma membrane (PubMed:21297635)|
|Tissue Location||Widely expressed, with strongest expression in placenta (at protein level). Secreted by synovial fibroblasts. Up- regulated in osteoarthritis and rheumatoid arthritis synovial fluids and cartilage as compared with non-arthritic (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Zumbrunn J.,et al.FEBS Lett. 398:187-192(1996).
Crowl R.M.,et al.Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Hu S.I.,et al.J. Biol. Chem. 273:34406-34412(1998).
De Luca A.,et al.J. Histochem. Cytochem. 52:885-892(2004).
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