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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   HTRA1 antibody - N-terminal region   

HTRA1 antibody - N-terminal region

Rabbit Polyclonal Antibody

  • WB - HTRA1 antibody - N-terminal region AI14977

    WB Suggested Anti-HTRA1 Antibody Titration: 1.0 μg/ml
    Positive Control: Fetal Kidney
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q92743
Other Accession NM_002775, NP_002766
Reactivity Human, Mouse, Rat, Pig, Bovine
Predicted Human, Mouse, Rat, Pig, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 53kDa
Additional Information
Gene ID 5654
Alias Symbol ARMD7, HtrA, L56, ORF480, PRSS11
Other Names Serine protease HTRA1, 3.4.21.-, High-temperature requirement A serine peptidase 1, L56, Serine protease 11, HTRA1, HTRA, PRSS11
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-HTRA1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsHTRA1 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HTRA1
Synonyms HTRA, PRSS11
Function Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.
Cellular Location Secreted. Cytoplasm, cytosol. Note=Predominantly secreted. Also found associated with the plasma membrane
Tissue Location Widely expressed, with strongest expression in placenta (at protein level). Secreted by synovial fibroblasts. Up- regulated in osteoarthritis and rheumatoid arthritis synovial fluids and cartilage as compared with non-arthritic (at protein level).
Research Areas
Citations (0)

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Zumbrunn J.,et al.FEBS Lett. 398:187-192(1996).
Crowl R.M.,et al.Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Hu S.I.,et al.J. Biol. Chem. 273:34406-34412(1998).
De Luca A.,et al.J. Histochem. Cytochem. 52:885-892(2004).

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$ 293.00
Cat# AI14977
(40 western blots)
Availability: 2-3 days
Bulk Size
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