|Other Accession||NM_001082, NP_001073|
|Reactivity||Human, Mouse, Rat, Rabbit, Goat, Sheep, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Pig, Sheep, Bovine|
|Other Names||Phylloquinone omega-hydroxylase CYP4F2, 220.127.116.11, 20-hydroxyeicosatetraenoic acid synthase, 20-HETE synthase, 1.14.13.-, Arachidonic acid omega-hydroxylase, CYPIVF2, Cytochrome P450 4F2, Cytochrome P450-LTB-omega, Leukotriene-B(4) 20-monooxygenase 1, Leukotriene-B(4) omega-hydroxylase 1, 18.104.22.168, CYP4F2 (HGNC:2645)|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-CYP4F2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||CYP4F2 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Omega-hydroxylase that oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids and xenobiotics. Plays a key role in vitamin K catabolism by mediating omega-hydroxylation of vitamin K1 (phylloquinone), and menaquinone-4 (MK-4), a form of vitamin K2. Hydroxylation of phylloquinone and MK-4 probably regulates blood coagulation (PubMed:19297519, PubMed:24138531). Also shows arachidonic acid omega-hydroxylase activity in kidney, by mediating conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), possibly influencing blood pressure control (PubMed:10660572, PubMed:17341693, PubMed:18574070). Also acts as a leukotriene-B(4) omega-hydroxylase by mediating conversion of leukotriene-B(4) (LTB4) to its omega-hydroxylated metabolite 20-hydroxyleukotriene- B(4) (20-OH LTB4) (PubMed:8026587, PubMed:9799565).|
|Cellular Location||Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein|
|Tissue Location||Liver. Also present in kidney: specifically expressed in the S2 and S3 segments of proximal tubules in cortex and outer medulla (PubMed:10660572).|
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Provided below are standard protocols that you may find useful for product applications.
Kikuta Y.,et al.FEBS Lett. 348:70-74(1994).
Kikuta Y.,et al.DNA Cell Biol. 18:723-730(1999).
Chen L.,et al.Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Grimwood J.,et al.Nature 428:529-535(2004).
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