|Other Accession||NM_000730, NP_000721|
|Reactivity||Human, Rat, Rabbit, Horse, Bovine, Guinea Pig|
|Predicted||Human, Rat, Rabbit, Horse, Bovine|
|Alias Symbol||CCK-A, CCK1-R, CCKRA|
|Other Names||Cholecystokinin receptor type A, CCK-A receptor, CCK-AR, Cholecystokinin-1 receptor, CCK1-R, CCKAR, CCKRA|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-CCKAR antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||CCKAR antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Ulrich C.D.,et al.Biochem. Biophys. Res. Commun. 193:204-211(1993).
Wank S.A.,et al.Biochem. Biophys. Res. Commun. 194:811-818(1993).
Miller L.J.,et al.Gastroenterology 109:1375-1380(1995).
Funakoshi A.,et al.FEBS Lett. 466:264-266(2000).
Kopatz S.A.,et al.Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
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