|Other Accession||NM_031430, NP_113618|
|Alias Symbol||FLJ31193, PP10141|
|Other Names||Rab-interacting lysosomal protein, RILP|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-RILP antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||RILP antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Rab effector playing a role in late endocytic transport to degradative compartments. Involved in the regulation of lysosomal morphology and distribution. Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments. Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes.|
|Cellular Location||Late endosome membrane Lysosome membrane Cytoplasmic vesicle, phagosome membrane. Note=Associated with late endosomal, lysosomal and phagosomal membranes. The interaction with RAB7A is necessary for its recruitment to phagosomes|
|Tissue Location||Ubiquitous. Strongly expressed in fetal heart, heart, stomach, spleen, adrenal gland, thyroid gland, salivary gland, fetal liver, liver and lung. Poorly expressed in brain|
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Provided below are standard protocols that you may find useful for product applications.
Cantalupo G.,et al.EMBO J. 20:683-693(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Wan D.,et al.Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
Frigimelica E.,et al.Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
Bucci C.,et al.Biochem. Biophys. Res. Commun. 286:815-819(2001).
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