|Other Accession||NM_006772, NP_006763|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Dog|
|Alias Symbol||DKFZp761G1421, KIAA1938, MRD5, RASA1, RASA5, SYNGAP|
|Other Names||Ras/Rap GTPase-activating protein SynGAP, Neuronal RasGAP, Synaptic Ras GTPase-activating protein 1, Synaptic Ras-GAP 1, SYNGAP1, KIAA1938|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-SYNGAP1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||SYNGAP1 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR- mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
Nagase T.,et al.DNA Res. 8:179-187(2001).
Mungall A.J.,et al.Nature 425:805-811(2003).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Krapivinsky G.,et al.Neuron 43:563-574(2004).
Hamdan F.F.,et al.N. Engl. J. Med. 360:599-605(2009).
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