|Other Accession||NM_001195381, NP_001182310|
|Reactivity||Human, Horse, Dog|
|Predicted||Human, Horse, Dog|
|Other Names||G-protein coupled receptor 35, Kynurenic acid receptor, KYNA receptor, GPR35|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-GPR35 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||GPR35 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity of this receptor is mediated by G-proteins that elicit calcium mobilization and inositol phosphate production through G(qi/o) proteins.|
|Cellular Location||Cell membrane; Multi-pass membrane protein Note=Internalized to the cytoplasm after exposure to kynurenic acid|
|Tissue Location||Predominantly expressed in immune and gastrointestinal tissues.|
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Provided below are standard protocols that you may find useful for product applications.
O'Dowd B.F.,et al.Genomics 47:310-313(1998).
Horikawa Y.,et al.Nat. Genet. 26:163-175(2000).
Warren C.N.,et al.Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
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